Prof. Debbie E. Shalev

Associate Professor

Tel: +972-2-658-1830
Mail: debbie@jce.ac.il

Positions:

Head of the Department of Pharmaceutical Engineering

Chairman of the Committee of Internationalization

Research Interests:

Structural analysis of peptide, protein and polymer systems by nuclear magnetic resonance (NMR) and other spectroscopic and thermoanalytical methods

Representative Publications:

1. Cyclizing painkillers: development of backbone cyclic TAPS analogs, A. Talhami, A. Swed, S, Hess, S. Greenberg, O. Ovadia, D. Rosenthal, D.E. Shalev, M. Hurevich, A. Hoffman, C. Gilon, Front Chem. 2020, 10, 1030. DOI: 10.3389/fchem.2020.532577

2. Mass spectrometry reveals the chemistry of formaldehyde cross-linking in structured proteins, T Tayri-Wilk, M Slavin, J Zamel, A Blass, S Cohen, A Motzik, Xue Sun, DE Shalev, O Ram, and N Kalisman, Nature Comm 2020 , 11(1), 1-19. doi.org/10.1038/s41467-020-16935-w

3. A Rapid and Efficient Building Block Approach for Click Cyclization of Peptoids. Samarasimhareddy M, Shamir M, Shalev DE, Hurevich M, Friedler A. Front Chem. 2020;8:405. doi: 10.3389/fchem.2020.00405.

4. High modulus thermoplastic segmented polyurethane/poly(L-lactide) blends as potential candidates for structural implantable drug delivery systems: I. Structure-properties relationship study, A Penhasi, A Gertler, I Baluashvili, O Elzinaty, DE Shalev, J Appl Polym Sci. 2020; e49517. doi: 10.1002/app.49517 – chosen for Cover figure

5. A novel nicotine pectinate salt formulated in a specific time-controlled delivery system: A new approach for colon-targeted nicotine release, Penhasi A, Gomberg M, Shalev DE, Journal of Drug Delivery Science and Technology. 2020 doi: 10.1016/j.jddst.2020.101583

6. Substitution of an Internal Disulfide Bridge with a Diselenide Enhances both Foldability and Stability of Human Insulin. Weil-Ktorza O, Rege N, Lansky S, Shalev DE, Shoham G, Weiss MA, Metanis N., Chemistry. 2019; 25:8513-8521 doi: 10.1002/chem.201900892 – chosen for Cover figure

7. Tailoring the self-assembly of a tripeptide for the formation of antimicrobial surfaces. Nir S, Zanuy D, Zada T, Agazani O, Aleman C, Shalev DE, Reches M. Nanoscale. 2019;11(18):8752-8759 – chosen for inside front cover figure

8. The Bacterial Extracellular Matrix Protein TapA Is a Two-Domain Partially Disordered Protein. Abbasi R, Mousa R, Dekel N, Amartely H, Danieli T, Lebendiker M, Levi-Kalisman Y, Shalev DE, Metanis N, Chai L. Chembiochem. 2018; 20:355-359. doi: 10.1002/cbic.201800634 – chosen for cover figure

 

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