Prof. Debbie Shalev אודות המכללה

Prof. Debbie Shalev




Associate Professor

Department of Pharmaceutical Engineering
Azrieli College of Engineering Jerusalem
POB 3566, Jerusalem 9103501, Israel
Tel: +972-2-658-8000 Ext: 8312
Fax: +972-2-659-1800
Mail: debbie@jce.ac.il
Web: www.jce.ac.il

 


Positions:

Associate Professor of Chemistry
Head of the Department of Pharmaceutical Engineering

 

Research Interests:

  • Structural Biological studies of peptides.
  • Protein-peptide and Protein-protein interactions.

 

Representative Publications:

  1. Backbone cyclic helix mimetic of chemokine (C-C motif) receptor 2: A rational approach for inhibiting dimerization of G protein-coupled receptors. Hurevich M., Ratner-Hurevich M., Tal-Gan Y.,Shalev D.E., Ben-Sasson S.Z., Gilon C. Bioorg Med Chem. 2013 21(13):3958-66.
  2. Structure and Coordination Determination of Peptide-Metal Complexes Using 1D and 2D 1H NMR. Shoshan, M.S., Tshuva, E., Shalev, D.E., 2013 J Vis Exp. 2013 Dec 16;(82):e50747.
  3. A Tandem In Situ Peptide Cyclization through Trifluoroacetic Acid Cleavage. Chandra K., Roy T.K., Shalev D.E., Loyter A., Gilon C., Gerber R.B., Friedler A. Angew Chem Int Ed Engl. 2014 53(36):9450-5.
  4. Allosteric Inhibition of G-Protein Coupled Receptor Oligomerization: Strategies and Challenges for Drug Development. Hurevich M., Talhami A., Shalev D.E., Gilon C. Curr Top Med Chem. 2014; 14(15):1842-63. Review.
  5. Unbound position II in MXCXXC metallochaperone model peptides impacts metal binding mode and reactivity: Distinct similarities to whole proteins. Shoshan MS, Dekel N, Goch W,Shalev DE, Danieli T, Lebendiker M, Bal W, Tshuva EY., J Inorg Biochem. 2016; 159: 29-36.

 

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